Potential therapeutic target identification in the novel 2019 coronavirus: insight from homology modeling and blind docking study

Egyptian Journal of Medical Human Genetics

Table 4 Calculated physiochemical properties by the ExPASy ProtParam server

Calculated parameters	Template protein	Target protein
Molecular weight	33845.72	33796.64
Theoretical pI	6.22	5.95
Amino acid composition (total)	306	306
Atomic composition	C₁₄₉₉H₂₃₂₅N₄₀₅O₄₄₅S₂₂	C₁₄₉₉H₂₃₁₈N₄₀₂O₄₄₅S₂₂
Extinction coefficient	33640	33640
Estimated half-life	30 h (mammalian reticulocytes, in vitro).	30 h (mammalian reticulocytes, in vitro).
	> 20 h (yeast, in vivo).	> 20 h (yeast, in vivo).
	> 10 h (Escherichia coli, in vivo).	>10 h (Escherichia coli, in vivo).
Instability index	29.67	27.65
Aliphatic index	81.83	82.12
GRAVY	− 0.049	− 0.019