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Table 1 Demographic and clinical characteristics of patients and controls at the start of the study (the first assessment)

From: COL1A1 polymorphism and neurological complications in pediatric acute lymphoblastic leukemia patients and their associations with altered bone mineral density

  Patients (no. 100) Controls (no. 100) p value
Sex (girls/boys) 58 (58%)/42 (42%) 57 (57%)/43 (43%) 0.5
Age/year 11 (± 4) 10 (± 3.5) 0.2
Age ≤ 10 years 40 (40%) 36 (36%) 0.4
> 10 years 60 (60%) 64 (64%)
BMI percentile 84th (70th–90th) 86th (68th–89th) 0.1
BMDLS − 1.9 (± 0.44) − 0.80 (± 0.73) 0.01*
Risk groups High 45 (45%)
Standard 55 (55%)
Parathormon (ng/l) 45 (10–56) 50 (12–60) 0.8
Total calcium (mg/ml) 9 ± 0.9 10 ± 0.14 0.2
Vitamin D (nmol/l) 44 (6–59) 41 (8–61) 0.4
Osteocalcin (ng/ml) 18 (8–23) 27 (8–30) 0.03*
Alkaline phosphatase (U/L) 99 (60–135) 440 (92–590) 0.01*
COLIA1 Genotypes G/G 55 (55%) 72 (72%) 0.05
G/T 34 (34%)* 19 (19%) 0.02*
T/T 11 (11%) 9 (9%) 0.5
Alleles G 130 (65%) 180 (90%) 0.04
T 70 (35%)* 20 (10%) 0.01*
  1. BMI body mass index, BMDLS bone mineral density of lumbar spine, COLIA1 collagen type 1alpha gene
  2. *Significant