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Egyptian Journal of Medical Human Genetics

Table 1 Demographic and clinical characteristics of patients and controls at the start of the study (the first assessment)

From: COL1A1 polymorphism and neurological complications in pediatric acute lymphoblastic leukemia patients and their associations with altered bone mineral density

 

Patients (no. 100)

Controls (no. 100)

p value

Sex (girls/boys)

58 (58%)/42 (42%)

57 (57%)/43 (43%)

0.5

Age/year

11 (Âħ 4)

10 (Âħ 3.5)

0.2

Age

≤ 10 years

40 (40%)

36 (36%)

0.4

> 10 years

60 (60%)

64 (64%)

BMI percentile

84th (70th–90th)

86th (68th–89th)

0.1

BMDLS

− 1.9 (Âħ 0.44)

− 0.80 (Âħ 0.73)

0.01*

Risk groups

High

45 (45%)

–

–

Standard

55 (55%)

–

Parathormon (ng/l)

45 (10–56)

50 (12–60)

0.8

Total calcium (mg/ml)

9 Âħ 0.9

10 Âħ 0.14

0.2

Vitamin D (nmol/l)

44 (6–59)

41 (8–61)

0.4

Osteocalcin (ng/ml)

18 (8–23)

27 (8–30)

0.03*

Alkaline phosphatase (U/L)

99 (60–135)

440 (92–590)

0.01*

COLIA1

Genotypes

G/G

55 (55%)

72 (72%)

0.05

G/T

34 (34%)*

19 (19%)

0.02*

T/T

11 (11%)

9 (9%)

0.5

Alleles

G

130 (65%)

180 (90%)

0.04

T

70 (35%)*

20 (10%)

0.01*

  1. BMI body mass index, BMDLS bone mineral density of lumbar spine, COLIA1 collagen type 1alpha gene
  2. *Significant
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