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Table 6 Multivariate analyses of different risk factors affecting bone mineral density of lumbar spine (BMDLS) in acute lymphoblastic leukemia patients after 3 years (the second assessment)

From: COL1A1 polymorphism and neurological complications in pediatric acute lymphoblastic leukemia patients and their associations with altered bone mineral density

Risk factors

Population

BMDLS

OR [95% CI]

p value

Sex

Girls (58%)

1.336 Âħ 0.44

5.5 [0.2–8.7]

0.5

Boys (42%)

1.356 Âħ 0.64

BMI percentile

> 85th (55%)

1.735 Âħ 0.14

3.9 [0.12–8.97]

0.6

≤ 85th 10 (45%)

1.04 Âħ 0.24

Neurological complications

Detected (24%)

2.13 Âħ 0.60

9.9 [10.2–13.3]

0.04*

Not detected (76%)

1.29 Âħ .002

Risk groups

High risk (45%)

2.931 Âħ 0.60

6.1 [10.2–13.3]

0.01*

Standard risk (55%)

1. 690 Âħ 0.11

Age at diagnosis

> 10 years (60%)

2.28 Âħ 0.06

5.9 [13.9–14.67]

0.01*

≤ 10 years (40%)

1.06 Âħ 0.44

COLIA1 (alleles)

T (35%)

2.645 Âħ 0.91

5.5 [11.9–22.1]

0. 03*

G (65%)

0.947 Âħ 0.13

  1. BMDLS bone mineral density of lumbar spine, BMI body mass index, COLIA1 collagen type 1 alpha gene