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Table 6 Multivariate analyses of different risk factors affecting bone mineral density of lumbar spine (BMDLS) in acute lymphoblastic leukemia patients after 3 years (the second assessment)

From: COL1A1 polymorphism and neurological complications in pediatric acute lymphoblastic leukemia patients and their associations with altered bone mineral density

Risk factors Population BMDLS OR [95% CI] p value
Sex Girls (58%) 1.336 ± 0.44 5.5 [0.2–8.7] 0.5
Boys (42%) 1.356 ± 0.64
BMI percentile > 85th (55%) 1.735 ± 0.14 3.9 [0.12–8.97] 0.6
≤ 85th 10 (45%) 1.04 ± 0.24
Neurological complications Detected (24%) 2.13 ± 0.60 9.9 [10.2–13.3] 0.04*
Not detected (76%) 1.29 ± .002
Risk groups High risk (45%) 2.931 ± 0.60 6.1 [10.2–13.3] 0.01*
Standard risk (55%) 1. 690 ± 0.11
Age at diagnosis > 10 years (60%) 2.28 ± 0.06 5.9 [13.9–14.67] 0.01*
≤ 10 years (40%) 1.06 ± 0.44
COLIA1 (alleles) T (35%) 2.645 ± 0.91 5.5 [11.9–22.1] 0. 03*
G (65%) 0.947 ± 0.13
  1. BMDLS bone mineral density of lumbar spine, BMI body mass index, COLIA1 collagen type 1 alpha gene