Table 2 Results of karyotyping, FISH analysis, mutational screening and BECN1 expression
From: Reductive regulation of BECN1 gene in adult Egyptian patients with do novo AML
Case number | Conventional karyotyping | FISH results | FLT3-ITD/c-Kit/Nucleophosmin mutational status | BECN1 expression |
|---|---|---|---|---|
1 | Normal karyotype | t(8;21) Negative | FLT3-ITD Positive | 0.37(RE) |
2 | Trisomy 8 | t(9;22)Negative | 0.13(RE) | |
3 | Normal karyotype | 11q23 Negative | WT NPM1 | 0.62(RE) |
4 | Normal karyotype | t(9;22)Negative | Mutated NPM1and FLT3-ITD | 0.58(RE) |
5 | t(8;21) Positive | t(8;21) Positive | cKIT Positive | 0.65(RE) |
6 | Normal karyotype | t(8;21) Negative | FLT3-ITD Positive | 0.18(RE) |
7 | t(8;21) Positive | t(8;21) Positive | 1.03(NE) | |
8 | Variable rearrangement | t(8;21) Positive | cKIT Positive | 0.51(RE) |
9 | 17 p deletion | t(9;22)Negative | 0.33(RE) | |
10 | Normal karyotype | t(8;21) Negative | FLT3-ITD Positive | 0.62(RE) |
11 | Normal karyotype | t(9;22)Negative | Mutated NPM1and FLT3-ITD | 0.52(RE) |
12 | Normal karyotype | t(9;22)Negative | WT NPM1 | 0.35(RE) |
13 | t(15;17) Positive | t(15;17) Positive | 1.04(NE) | |
14 | t(15;17) Positive | t(15;17) Positive | 1.07(NE) | |
15 | t(9;22) Positive | t(9;22) Positive | 0.27(RE) | |
16 | Trisomy 8 | t(8;21) Negative | 0.54(RE) | |
17 | Variable rearrangement | t(8;21) Positive | cKIT Positive | 0.26(RE) |
18 | t(9;22) Positive | t(9;22) Positive | FLT3-ITD Positive | 0.34(RE) |
19 | Normal karyotype | Inv16 Positive | 0.64(RE) | |
20 | t(9;22) Positive | t(9;22) Positive | 1.05(NE) | |
21 | t(8;21) Positive | t(8;21) Positive | 1.07(NE) | |
22 | Normal karyotype | t(8;21) Negative | FLT3-ITD Positive | 0.31(RE) |
23 | t(15;17) Positive | t(15;17) Positive | 0.29(RE) | |
24 | Trisomy 8 | t(8;21) Negative | 0.28(RE) | |
25 | Normal karyotype | t(9;22) Negative | WT NPM1 | 0.29(RE) |
26 | Normal karyotype | t(9;22) Negative | FLT3-ITD Positive | 0.31(RE) |
27 | t(8;21) Positive | t(8;21) Positive | cKIT Positive | 1.02(NE) |
28 | Normal karyotype | t(8;21) Negative | FLT3-ITD Positive | 0.36(RE) |
29 | 11q23 Positive | 11q23 Positive | 0.27(RE) | |
30 | Variable rearrangement | t(8;21) Positive | FLT3-ITD Positive | 0.33(RE) |
31 | Monosomy 7 | t(9;22) Negative | 1.04(NE) | |
32 | Inv16 Positive | Inv16 Positive | cKIT Positive | 0.26(RE) |
33 | 11q23 Positive | 11q23 Positive | 0.17(RE) | |
34 | Normal karyotype | t(9;22) Negative | FLT3-ITD Positive | 0.34(RE) |
35 | Normal karyotype | Inv16 Positive | 1.04(NE) | |
36 | t(8;21) Positive | t(8;21) Positive | 1.06(NE) | |
37 | Double Philadelphia | t(9;22) Positive | 0.29(RE) | |
38 | Normal karyotype | t(9;22) Negative | FLT3-ITD Positive | 0.26(RE) |
39 | Inv16 Positive | Inv16 Positive | cKIT Positive | 0.32(RE) |
40 | Normal karyotype | Inv16 Negative | WT NPM | 1.08(NE) |
41 | Inv16 Positive | Inv16 Positive | 1.07(NE) | |
42 | t(15;17) Positive | t(15;17) Positive | 1.03(NE) | |
43 | Normal karyotype | t(8;21) Negative | FLT3-ITD Positive | 0.45(RE) |
44 | Normal karyotype | t(8;21) Negative | FLT3-ITD Positive | 0.16(RE) |
45 | t(8;21) Positive | t(8;21) Positive | cKIT Positive | 0.38(RE) |
46 | t(8;21) Positive | t(8;21) Positive | cKIT Positive | 1.06(NE) |
47 | Normal karyotype | t(8;21) Negative | FLT3-ITD Positive | 0.43(RE) |
48 | Normal karyotype | Inv16 Negative | FLT3-ITD Positive | 0.61(RE) |
49 | t(15;17) Positive | t(15;17) Positive | 1.04(NE) | |
50 | Normal karyotype | t(9;22) Negative | WT NPM | 0.36(RE) |