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Table 4 Comparison between normal and reduced BECN1 gene expression groups

From: Reductive regulation of BECN1 gene in adult Egyptian patients with do novo AML

Parameter BECN1gene expression Test value P value Sig.
Normal (n = 14) Reduced (n = 36)
Sex [n (%)]  
 Females 6 (42.9%) 22 (61.1%) 1.363* 0.243 NS
 Males 8 (57.1%) 14 (38.9%)
Age (years)  
 Mean ± SD 33.86 ± 15.92 58.44 ± 17.37 − 4.596 0.000 HS
 Range (18–70) (19–78)
Clinical data [n (%)]  
 Fever 3(21.4%) 8(22.2%) 0.004* 0.951 NS
 Hepatomegaly 4(28.6%) 15(41.7%) 0.734* 0.392
 Splenomegaly 5(35.7%) 14(38.9%) 0.043* 0.836
 Lymphadenopathy 0(0.0%) 4(11.1%) 1.691* 0.193
TLC (× 109/L) Median (IQR) 20.3 (13.3–35.4) 65.15 (37.3–83.05) 3.824 0.000 HS
Hb (g/dl) Mean ± SD 8.09 ± 2.31 8.09 ± 1.92 0.002 0.999 NS
PLT (× 109/L) Median(IQR) 41 (28–68) 30.5 (20–67.5) − 0.908 0.364 NS
PB blasts (%)Mean ± SD 40.71 ± 20.33 63.28 ± 21.64 − 3.364 0.002 HS
BM blasts (%)Mean ± SD 63.07 ± 22.17 80.58 ± 18.34 − 2.858 0.006 HS
Immunophenotyping [n (%)]
 CD34 + 5 (35.7%) 28 (77.8%) 7.948* 0.005 HS
 CD117 + 5 (35.7%) 27 (75.0%) 6.752* 0.009 HS
 HLA-DR + 11 (78.6%) 32 (88.9%) 0.891* 0.345 NS
FAB subtypes [n (%)]  
 M0 0 (0.0%) 5 (13.9%) 9.106* 0.105 NS
 M1 2 (14.3%) 8 (22.2%)
 M2 5 (35.7%) 15 (41.7%)
 M3 4 (28.6%) 1 (2.8%)
 M4 3 (21.4%) 4 (11.1%)
 M5 0 (0.0%) 3 (8.3%)
Molecular abnormalities [n (%)]
 Wild type NPM1 1 (7.1%) 4 (11.1%) 0.176* 0.675 NS
 Mutated NPM1 and FLT3-ITD 0 (0.0%) 2 (5.6%) 0.81* 0.368 NS
 FLT3-ITD mutation 0 (0.0%) 14 (38.9%) 7.562* 0.006 HS
 c-KIT mutation 2 (14.3%) 6 (16.7%) 0.043* 0.837 NS
Cytogenetic risk groups [n (%)]
 Favourable 9 (81.8%) 2 (18.2%) 20.314* 0.000 HS
 Intermediate 1 (10.0%) 9 (90.0%)
 Adverse 4 (13.8%) 25 (86.2%)
Response to induction therapy (D28) [n (%)]
 Non- responders 4 (28.6%) 31 (86.1%) 15.892* 0.000 HS
 Responders 10(71.4%) 5 (13.9%)
  1. P value > 0.05: non-significant (NS); P value < 0.05: significant (S); P value < 0.01: highly significant (HS), n number
  2. *Chi-square test
  3. Independent t test
  4. Mann-Whitney test