Role of interleukins 12B and 17A genetic variation in house dust mites allergy

Egyptian Journal of Medical Human Genetics

Table 7 Genotype and allele frequencies of IL12B (+1188 A/C) and IL17A (−197G/A) polymorphisms among studied groups

The studied parameter		Controls N = 60 (%)	Asthma N = 20 (%)	AR N = 20 (%)	Dermatitis N = 20 (%)
IL12B (+1188 A/C)	Genotype
	AA	54 (90.0)	6 (30.0)	8 (40.0)	4(20.0)
	AC	6 (10.0)	14 (70.0)	10 (50.0)	16 (80.0)
	CC	0 (0.0)	0 (0.0)	2 (10 .0)	0 (0.0)
	p value		.020*	< .001**	.005**
	Allele
	A	114 (95.0)	26 (65.0)	26 (65.0)	24 (60.0)
	C	6 (5.0)	14 (35.0)	14 (35.0)	16 (40.0)
	p value		.043*	.043*	.019*
IL17 (−197G/A)	Genotyping
	GG	48(80.0)	8 (40.0)	4 (20.0)	4(20.0)
	GA	6 (10.0)	12(60.0)	12(60.0)	14(70.0)
	AA	6 (10.0)	0 (0.0)	4(20.0)	2(10.0)
	p value		.057	< .001**	< .001**
	Allele
	G	102 (85.0)	28 (70.0)	20 (50.0)	22 (55.0)
	A	18 (15.0)	12 (30.0)	20 (50.0)	18 (45.0)
	p value		.450	.018*	.038*

Fisher exact test was used. All parameters represented as number and percent. *p value ≤ 0.05 significant while **p value ≤ 0.01 highly significant and p > 0.05 non-significant