Fig. 2

Action of host cell proteases on ACE2 receptor [adapted from 35]. Cleavage of ACE2 by ADAM17 causes its shedding. Interaction of sACE2 with S-Protein of SARS-CoV prevents binding of virus particles to target cells. Co-expression of TMPRSS2 with ACE2 on target cell surface involves binding of SARS-CoV (S-protein) to ACE2- and TMPRSS2-mediated processing allows fusion and uptake of virus particles