Fig. 3
From: COVID-19 susceptibility: potential of ACE2 polymorphisms
Possible role of novel ACE2 SNPs in susceptibility towards SARS-CoV-2. Presence of SNPs within coding region can result in alteration of amino acid sequence. This change in amino acid sequence at site of interaction can affect the binding capacity of ACE2 receptor with S-Protein of SARS-CoV-2. Novel SNPs within promoter or 3′-UTR can cause downregulation of ACE2 gene resulting in lower levels of ACE2 receptor at cell surface for interaction with virus particles