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Table 8 Association between rs11536858 genotype and epilepsy drugs used

From: The association between toll-like receptor 4 (TLR4) genotyping and the risk of epilepsy in children

Drug

rs11536858 genotype

χ2

p

GG

n = 6(%)

GA

n = 30(%)

AA

n = 47(%)

Na valproate

6 (100)

29 (96.7)

39 (83.0)

4.3

0.11

Carbamazepine

1 (16.7)

4 (13.3)

14 (29.8)

2.9

0.23

Levitracetapine

5 (83.3)

17 (56.7)

24 (51.1)

2.3

0.32

Oxacarbamazepine

0

4 (13.3)

6 (1.8)

0.9

0.64

Topiramate

3 (50.0)

10 (33.3)

12 (25.5)

1.7

0.42

Clonazepam

4 (66.7)

1 (3.3)

2 (4.3)

28.4

< 0.001*

Phenytoin

0

2 (6.7)

1 (2.1)

1.3

0.52

Lacosamide

0

0

1 (2.1)

0.78

0.68

Lamotrigine

0

1 (3.3)

3 (6.4)

0.69

0.71

  1. Statistically significant association between clonazepam resistance and rs11536858 as p value < 0.001* with the highest frequency with AA genotypes (4.3) %