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Table 5 Allele and genotype frequencies of HLA-G 14 bp insertion/deletion polymorphism in inflammatory bowel disease (ulcerative colitis and Crohn’s disease) patients and controls

From: Susceptibility role of soluble HLA-G and HLA-G 14-bp insertion/deletion polymorphism in inflammatory bowel disease

Genetic model

Allele/Genotype

HC (N = 100)

IBD (N = 100)

UC (N = 50)

CD (N = 50)

N (%)

N (%)

OR (95% CI)

p (pc)

N (%)

OR (95% CI)

p (pc)

N (%)

OR (95% CI)

p (pc)

Allele

Ins

82 (41.0)

53 (26.5)

Reference

 

28 (28.0)

Reference

 

25 (25.0)

Reference

 

Del

118 (59.0)

147 (73.5)

1.93 (1.27–2.94)

0.003 (0.018)

72 (72.0)

1.79 (1.07–3.00)

0.031 (NS)

75 (75.0)

2.08 (1.23–3.54)

0.007 (0.042)

Recessive

Del/Del

38 (38.0)

54 (54.0)

Reference

 

27 (54.0)

Reference

 

27 (54.0)

Reference

 

Ins/Del + Ins/Ins

62 (62.0)

46 (46.0)

1.92 (1.09–3.37)

0.024 (NS)

23 (46.0)

1.92 (0.96–3.81)

0.064 (NS)

23 (46.0)

1.92 (0.96–3.81)

0.064 (NS)

Dominant

Ins/Ins

20 (20.0)

7 (7.0)

Reference

 

5 (10.0)

Reference

 

2 (4.0)

Reference

 

Ins/Del + Del/Del

80 (80.0)

93 (93.0)

3.32 (1.34–8.26)

0.010 (NS)

45 (90.0)

2.25 (0.79–6.40)

0.129 (NS)

48 (96.0)

6.00 (1.34–26.81)

0.019 (NS)

Overdominant

Ins/Del

42 (42.0)

39 (39.0)

Reference

 

18 (36.0)

Reference

 

21 (42.0)

Reference

 

Ins/Ins + Del/Del

58 (58.0)

61 (61.0)

1.13 (0.64–1.99)

0.666 (NS)

32 (64.0)

1.29 (0.64–2.60)

0.408 (NS)

29 (58.0)

1.00 (0.50–1.99)

1.000 (NS)

Codominant

Ins/Ins

20 (20.0)

7 (7.0)

Reference

 

5 (10.0)

Reference

 

2 (4.0)

Reference

 

Ins/Del

42 (42.0)

39 (39.0)

2.65 (1.01–6.96)

0.047 (NS)

18 (36.0)

7.11 (1.53–32.98)

0.012 (NS)

21 (42.0)

5.00 (1.07–23.44)

0.041 (NS)

Del/Del

38 (38.0)

54 (54.0)

4.06 (1.56–10.56)

0.004 (0.024)

27 (54.0)

2.84 (0.95–8.51)

0.062 (NS)

27 (54.0)

1.71 (0.56–5.28)

0.384 (NS)

HWE-p

 

0.187

 

0.991

 

0.449

  

0.396

  
  1. Significant p is bold-marked
  2. Ins insertion, Del deletion, HC healthy control, IBD inflammatory bowel disease, UC ulcerative colitis, CD Crohn’s disease, OR odds ratio, CI confidence interval, p probability, pc Bonferroni-corrected p, NS not significant (p > 0.05), HWE Hardy-Weinberg equilibrium