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Fig. 6 | Egyptian Journal of Medical Human Genetics

Fig. 6

From: An in silico LLPS perturbation approach in the design of a novel SARS-CoV-2 spike receptor-binding domain inhibitor

Fig. 6

The liquid-liquid phase separation propensity profile plot of the wild-type and variant SARS-CoV-2 spike receptor-binding domain (a and b), respectively. The variant produced a reduced propensity score of 0.335 as against the propensity score of the wild type (0.388). The effect of the deleted residues on the propensity profiles of the two proteins is shown using arrows. The mutation caused a drastic reduction in the peaks of the variant (b) as compared to the wild-type protein (a). This shows the importance of the deleted residues in the liquid-liquid phase separation and functionality of the viral protein

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