Skip to main content

Table 3 ADME properties of ten top compounds

From: Structure-based design of some quinazoline derivatives as epidermal growth factor receptor inhibitors

Molecule GI absorption BBB permeant Pgp substrate Bioavailability score Synthetic accessibility
Molecule 3 Low No No 0.55 3.54
Molecule 5 Low No Yes 0.55 4.18
Molecule 6 High No Yes 0.55 4.11
Molecule 7 High No Yes 0.55 4.16
Molecule 9 High No No 0.55 3.67
Molecule 12 High No No 0.55 3.58
Molecule 22 High No Yes 0.55 4.63
Molecule 29 High No Yes 0.55 4.32
Molecule 34 Low No Yes 0.55 4.67
Molecule 43 High No Yes 0.55 3.48