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Table 7 ADME properties of the newly designed compounds

From: Structure-based design of some quinazoline derivatives as epidermal growth factor receptor inhibitors

Molecule GI absorption BBB permeant Pgp substrate Bioavailability score Synthetic accessibility
Molecule 1 Low No No 0.55 4.67
Molecule 2 Low No No 0.55 4.88
Molecule 3 Low No No 0.55 4.67
Molecule 4 Low No No 0.55 4.66
Molecule 5 Low No No 0.55 4.67
Molecule 6 Low No No 0.55 4.67
Molecule 7 Low No No 0.55 4.67
Molecule 8 Low No No 0.55 4.87
Molecule 9 Low No No 0.17 5.16
Molecule 10 Low No No 0.55 4.84
Molecule 11 Low No No 0.55 4.86
Molecule 12 Low No No 0.55 4.83
Molecule 13 Low No No 0.17 4.68
Molecule 14 Low No No 0.17 4.69
Molecule 15 Low No No 0.55 4.87
Molecule 16 Low No No 0.55 4.87