Table 7 ADME properties of the newly designed compounds
Molecule | GI absorption | BBB permeant | Pgp substrate | Bioavailability score | Synthetic accessibility |
|---|---|---|---|---|---|
Molecule 1 | Low | No | No | 0.55 | 4.67 |
Molecule 2 | Low | No | No | 0.55 | 4.88 |
Molecule 3 | Low | No | No | 0.55 | 4.67 |
Molecule 4 | Low | No | No | 0.55 | 4.66 |
Molecule 5 | Low | No | No | 0.55 | 4.67 |
Molecule 6 | Low | No | No | 0.55 | 4.67 |
Molecule 7 | Low | No | No | 0.55 | 4.67 |
Molecule 8 | Low | No | No | 0.55 | 4.87 |
Molecule 9 | Low | No | No | 0.17 | 5.16 |
Molecule 10 | Low | No | No | 0.55 | 4.84 |
Molecule 11 | Low | No | No | 0.55 | 4.86 |
Molecule 12 | Low | No | No | 0.55 | 4.83 |
Molecule 13 | Low | No | No | 0.17 | 4.68 |
Molecule 14 | Low | No | No | 0.17 | 4.69 |
Molecule 15 | Low | No | No | 0.55 | 4.87 |
Molecule 16 | Low | No | No | 0.55 | 4.87 |