In silico analysis of non-synonymous single nucleotide polymorphisms of human DEFB1 gene

Egyptian Journal of Medical Human Genetics

Table 1 List of nsSNPs of the DEFB1 gene predicted as deleterious by different bioinformatics tools

SNP ID	Amino acid change	SIFT prediction	PolyPhen score	PolyPhen prediction	PROVEAN score	PROVEAN prediction	SNAP prediction	PhD-SNP prediction	SNPs&GO prediction
rs1800968	C67S	Deleterious	0.999	Probably damaging	− 9.697	Deleterious	Effect	Disease	Disease
rs55874920	T58S	Deleterious	0.967	Probably damaging	− 3.879	Deleterious	Effect	Neutral	Neutral
rs56270143	G62W	Deleterious	0.999	Probably damaging	− 6.121	Deleterious	Effect	Disease	Neutral
rs140503947	Y35C	Deleterious	0.984	Probably damaging	− 8.636	Deleterious	Effect	Disease	Disease
rs145468425	G57R	Deleterious	1	Probably damaging	− 7.758	Deleterious	Effect	Disease	Disease
rs146603349	P50Q	Deleterious	0.904	Possibly damaging	− 8.00	Deleterious	Effect	Disease	Disease
rs199581284	C44R	Deleterious	0.999	Probably damaging	− 12.00	Deleterious	Effect	Disease	Disease
rs201260899	C44Y	Deleterious	0.999	Probably damaging	− 11.00	Deleterious	Effect	Disease	Disease
rs371897938	G21R	Deleterious	0.948	Probably damaging	− 4.242	Deleterious	Effect	Disease	Disease
rs376876621	C59Y	Deleterious	0.999	Probably damaging	− 10.667	Deleterious	Effect	Disease	Disease