Table 3 Prediction of phylogenetic conservation and post-translational modifications
From: In silico analysis of non-synonymous single nucleotide polymorphisms of human DEFB1 gene
SNP ID | Amino acid change | ConSurf conservation score | Functional/structural | Post-translational modification |
|---|---|---|---|---|
rs1800968 | C67S | 9/conserved | f | Disulfide linkage |
rs55874920 | T58S | 8/conserved | f | Amidation, O-linked glycosylation |
rs56270143 | G62W | 6/intermediately conserved | - | - |
rs140503947 | Y35C | 7/conserved | - | Amidation |
rs145468425 | G57R | 9/conserved | s | - |
rs146603349 | P50Q | 9/conserved | s | - |
rs199581284 | C44R | 9/conserved | s | Disulfide linkage |
rs201260899 | C44Y | 9/conserved | s | - |
rs371897938 | G21R | 7/conserved | - | - |
rs376876621 | C59Y | 9/conserved | s | Disulfide linkage |