Table 3 Top 5 signalling pathways associated with the DEGs in primary glial tumours
From: Integrative analysis of mRNA and miRNA sequencing data for gliomas of various grades
Signalling pathway (identified via DAVID) | Number of DEGs | -log10(FDR) | Number of DEGs | -log10(FDR) | Number of DEGs | -log10(FDR) | Number of DEGs | -log10(FDR) | Number of DEGs | -log10(FDR) |
|---|---|---|---|---|---|---|---|---|---|---|
Astrocytoma G2 | Oligodendroglioma G2 | Astrocytoma G3 | Oligodendroglioma G3 | Glioblastoma G4 | ||||||
Axonal guidance | 126 | 10 | 99 | 6.5 | 126 | 10 | x | x | 168 | 12 |
G protein-coupled receptor signalling | 86 | 9.8 | Ñ… | Ñ… | x | x | 59 | 6 | x | x |
cAMP-mediated signalling | 75 | 9.5 | Ñ… | Ñ… | x | x | x | x | x | x |
EIF2 signalling | 72 | 15 | 58 | 11 | 64 | 10 | 64 | 13 | x | x |
Neuropathic pain signalling in dorsal horn neurons | 44 | 9 | 34 | 6 | 46 | 10 | x | x | x | x |
mTOR | Ñ… | Ñ… | 52 | 6.2 | x | x | 58 | 8 | x | x |
Dopamine–DARPP32 feedback in cAMP signalling | х | х | 46 | 6 | x | x | 48 | 6 | x | x |
Role of NFAT in cardiac hypertrophy | x | x | x | x | 65 | 9 | x | x | x | x |
Synaptic long-term potentiation | x | x | x | x | 48 | 8.5 | 40 | 6.2 | x | x |
Signalling by Rho family GTPases | x | x | x | x | x | x | x | x | 96 | 7.5 |
Breast cancer regulation by stathmin1 | x | x | x | x | x | x | x | x | 61 | 7 |
Molecular mechanisms of cancer | x | x | x | x | x | x | x | x | 127 | 6.5 |
IL-8 signalling | x | x | x | x | x | x | x | x | 79 | 6.5 |