Table 4 New unique patterns of DEGs associated with overall survival and not previously mentioned in glial tumour studies
From: Integrative analysis of mRNA and miRNA sequencing data for gliomas of various grades
Gene | LogFC | Functions | Association with survival in gliomasa | Association with survival in other cancers |
|---|---|---|---|---|
Diffuse astrocytoma | ||||
 FGFBP3 | 1.8 | Activation of FGFR signalling, resulting in increased vascular permeability | Positive | – |
 ZFP69 | 1.2 | Transcriptional factor | Positive | Negatively correlated with survival in kidney cancer; positively correlated with survival in head and neck cancer (TCGA) |
 C19orf18 | 2.3 | Transcriptional factor | Positive | Positively correlated with survival in endometrial cancer (TCGA) |
 RGS18 | 1.7 | Myeloerythroid lineage-specific regulator of G protein signalling | Positive | – |
 LUZP2 | 2.5 | A gene whose expression is specific to the spinal cord and brain | Positive | Positively correlated with survival in lung cancer (TCGA) |
 C15orf21 | 1.7 | Nucleosomal binding domain 2 | Positive | – |
 SEPHS1 | 1.1 | Synthesis of selenocysteine | Positive | Negatively correlated with survival in kidney cancer; positively correlated with survival in pancreatic cancer (TCGA) |
 BEST3 | 4.3 | Formation of Ca-dependent chloride channels | Positive | – |
 GIMAP8 | 1 | GTPase, has an antiapoptotic effect on the immune system and is involved in reactions to infections | Positive | Negatively correlated with survival in testicular cancer (TCGA) |
 PLBD2 | − 1.1 | Phospholipase B-like 2 | Negative | Negatively correlated with survival in kidney cancer (TCGA) |
 PCDHGA9 | − 2 | Calcium-dependent cell-cell adhesion | Negative | Positively correlated with survival in gastric cancer [15] |
 HSPA4L | − 1.2 | Chaperone protein that inhibits acetate synthase aggregation | Negative | Positively correlated with survival in kidney cancer; negatively correlated with survival in urothelial cancer (TCGA) |
 MAEL | − 1.3 | Involvement in the metabolism of secondary piRNA | Negative | Negatively correlated with survival in gastric cancer [16] |
 NCRNA00202 | − 2 | Non-coding RNA | Positive | – |
Anaplastic astrocytoma | ||||
 SMC5 | 1.1 | Chromosome segregation and DNA repair | Negative | Negatively correlated with survival in pancreatic cancer (TCGA) |
 CEP110 | 1.2 | Centrosome formation | Negative | Negatively correlated with survival in head and neck cancer (TCGA) |
 C2orf50 | − 2.5 | Uncharacterized protein C2orf50 | Negative | – |
 DHRS11 | − 1 | Dehydrogenase/reductase | Negative | Negatively correlated with survival in kidney cancer (TCGA) |
 MGC45800 | − 2.9 | Non-coding RNA | Negative | – |
 TLL1 | − 2.8 | Zinc-dependent metalloproteinase | Positive | Negatively correlated with survival in hepatocellular carcinoma [17] |
 TDRD6 | − 1.1 | Involved in cell differentiation | Positive | Positively correlated with survival in prostate cancer [18] |
 RP1-177G6.2 (LINC00632) | − 1.7 | Long intergenic non-coding RNA | Positive | Positively correlated with survival in breast cancer [19] |
 RFK | − 1 | Binding of proteins, ATP, and metals; riboflavin kinase activity | Negative | – |
Diffuse oligodendroglioma | ||||
 RCOR2 | 2.4 | DNA-binding transcription factor | Positive | Positively correlated with survival in prostate cancer (TCGA) |
 DCAF12L2 | − 2.2 | Involved in the regulation of the cell cycle, apoptosis and gene expression | Positive | – |
 TMEM171 | − 2.4 | Protein binding | Positive | Negatively correlated with survival in kidney cancer (TCGA) |
 AGPAT9 | − 2 | Participates in the biosynthesis of triglycerides and phosphatidic acid and the regulation of TOR signalling | Negative | – |
 C6orf105 (ADTRP) | − 3.1 | FAHFA lipid hydroxylation | Positive | Negatively correlated with survival in kidney cancer (TCGA) |
 C2orf15 | − 1.2 | RNA binding | Negative | Positively correlated with survival in kidney and ovarian cancer (TCGA) |
Anaplastic oligodendroglioma | ||||
 HKDC1 | 3.1 | Hexokinase activity | Positive | – |
 C6orf134 (ATAT1) | 1 | Tubulin-N-acetyltransferase activity | Positive | Negatively correlated with survival in kidney and liver cancer; positively correlated with survival in urothelial cancer (TCGA) |
 LOC283392 | − 2.2 | Unknown function | Positive | – |
 RPS6KA1 | − 1 | Serine/threonine kinase activity | Negative | Positively correlated with survival in cancer of the endometrium, kidney, and stomach; negatively correlated with survival in urothelial cancer (TCGA) |
 OLR1 | − 1.8 | Protein binding | Positive | Negatively correlated with survival in head and neck cancer (TCGA) |
Glioblastoma | ||||
 USP51 | − 1.1 | The binding of chromatin, zinc ions; thiol-dependent ubiquitin-specific protease activity | Positive | Positively correlated with survival in kidney and ovarian cancer (TCGA); negatively correlated with survival in pancreatic cancer [20] |
 TCP10L | − 1.3 | Transcriptional corepressor | Positive | – |
 KANK4 | − 2.7 | Negative regulation of actin filament polymerization | Negative | – |
 ANKRD16 | − 1.2 | tRNA modification | Positive | Negatively correlated with survival in kidney cancer; positively correlated with survival in pancreatic cancer (TCGA) |
 LRSAM1 | − 1 | Ubiquitin-protein transferase activity | Positive | Positively correlated with survival in pancreatic and kidney cancer (TCGA) |
 AGAP4 | − 1 | Positive regulation of GTPase activity | Positive | – |
 CDKL1 | − 1.3 | Cyclin-dependent protein serine/threonine kinase activity | Positive | – |
 FRY | − 1.8 | Negative regulation of catalytic activity | Positive | Positively correlated with survival in kidney cancer (TCGA) |
  ZNF774 | − 1.1 | The binding of metal ions, DNA and proteins | Positive | Positively correlated with survival in liver cancer [21] |
 CEP97 | − 1 | Protein binding | Positive | – |
 SLC2A11 | − 1.3 | Transmembrane glucose transport | Positive | Positively correlated with survival in kidney cancer and pancreatic cancer (TCGA) |
 ADAT3 | 1.3 | tRNA-specific adenosine deaminase activity | Positive | Positively correlated with survival in cancers of the stomach, head and neck (TCGA) |
 MAP3K20 | 1.2 | MAPKK activity | Positive | Negatively correlated with survival in kidney cancer (TCGA) |
 GPR89B | 1.6 | Voltage-gated ion channel | Negative | – |
 STARD3NL | 1.2 | Homodimerization, protein binding, cholesterol binding | Negative | Negatively correlated with survival in liver, head, and neck cancer; and positively correlated with survival in pancreatic cancer (TCGA) |
 EDARADD | 3 | Protein binding | Negative | Negatively correlated with survival in cancers of the liver, head and neck; positively correlated with survival in pancreatic cancer [22] |
 TMED9 | 1.1 | Syntaxin binding | Negative | Negatively correlated with survival in kidney cancer (TCGA) |
 ZDHHC12 | 1.7 | Protein-cysteine S-palmitoyltransferase activity | Negative | – |
 ZNF561 | 1.1 | Binding of metal ions and DNA | Positive | Positively correlated with survival in cancers of the kidney and ovary (TCGA) and colorectal cancer [23] |
 SRRM5 | 1.5 | The binding of metal ions, DNA, and proteins | Positive | Positively correlated with survival in pancreatic cancer (TCGA) |
 ZNF658 | 1 | Transcriptional regulator; the binding of metal ions and DNA | Positive | Negatively correlated with survival in cervical cancer (TCGA) |
 XPNPEP2 | 3.9 | Aminopeptidase activity | Positive | – |
 LOC407835 | 1.2 | MAPKK activity (pseudogene) | Positive | – |
 MTHFS | 1.4 | Binding of ATP, folic acid, and metal ions; 5-formyl tetrohydrofolate cyclo-ligase activity | Negative | Positively correlated with survival in kidney and liver cancer (TCGA) |