Understanding the genetic determinant of severity in viral diseases: a case of SARS-Cov-2 infection

Egyptian Journal of Medical Human Genetics

Table 2 Summary of some genetic variants and SNPs associated with viral infections

Classification	Viruses	Important viral genetic variants and SNPs
Virus entry receptor modifying enzyme	Norovirus and rotavirus	FUT2 [7, 14, 15]
Virus entry receptor modifying enzyme	SARS-CoV-2	ACE2 variants (Lys26Arg, Ile468Val, Ala627Val, Asn638Ser, Ser692Pro, Asn720Asp, Leu731Ile/Leu731Phe) [35] ACE2 SNPs (rs4646127, rs2158082, rs5936011, rs6629110, rs4830983, rs5936029) [35]
Innate signaling response	Influenza virus	TLR3, IRF7, IRF9, IFITM3 [7,8,9]
	Herpes simplex virus	TLR3, TRIF, TRAF3, IRF3 [7, 12, 13]
	Hepatitis C virus	TLR7IVS2-151G, TLR8-129G [36]
	SARS-CoV-2	TLR3, IRF7, TLR7 [6, 37]
MHC/HLA Class 1	HIV	HLA-B57, CCR5 [7, 10, 11]
	Dengue virus	HLA-A 0207 and HLA-B 51 [30, 33]
	SARS-CoV-1	HLA-B 4601, HLA-B 5401 [32]
	SARS-CoV-2	HLA-B 1503 [32]
MHC/HLA Class 2	Hepatitis C virus	HLA-DRB1 0301, DQB1 0301, DRB1 0101, DRB1 0401 [49–56]
MHC/HLA Class 2	SARS-CoV-2	HLA-DR [38]