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Egyptian Journal of Medical Human Genetics
Fig. 1 | Egyptian Journal of Medical Human Genetics

Fig. 1

From: Identification of the most potent acetylcholinesterase inhibitors from plants for possible treatment of Alzheimer’s disease: a computational approach

Fig. 1

Cholinergic hypothesis and role of AChE in AD development. ACh is synthesized by ChAT and released from the pre-synaptic neuron. The ACh mediates its effects on the post-synaptic neuron through nicotinic and/or muscarinic receptors. The ACh then performs the downstream signaling in the post-synaptic neuron. AChE enzyme breaks down the ACh and overexpression of AChE lowers the amount of ACh in the brain which leads to the AD onset. AChE inhibitors repress the AChE activity, thus aid in the AD treatment

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