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Table 10 Overall comparison of the main features of bellidifolin, naringenin, apigenin, and coptisine as potential drugs to treat AD according to the study along with the 2 positive controls from comparison. All the compounds are ranked (excellent, good, and poor) based on their performance in every aspect

From: Identification of the most potent acetylcholinesterase inhibitors from plants for possible treatment of Alzheimer’s disease: a computational approach

Features Bellidifolin Naringenin Apigenin Coptisine Donepezil (positive control 1) Galantamine (positive control 2) Remarks (Best performers)
Molecular docking study Good Good Good Excellent Good Poor Coptisine
Druglikeness properties Excellent Excellent Excellent Excellent Excellent Excellent All
Absorption Excellent Excellent Excellent Poor Good Poor Bellidifolin, naringenin, apigenin
Distribution Excellent Excellent Poor Poor Excellent Good Bellidifolin, naringenin
Metabolism Excellent Poor Good Good Good Excellent Bellidifolin
Excretion Good Good Good Excellent Excellent Excellent Coptisine
Toxicity Good Excellent Good Excellent Excellent Excellent Naringenin & apigenin
PASS Prediction Good Good Good Good Good Good All
P450 SOM Good Excellent Excellent Poor Good Good Naringenin, apigenin
DFT calculations Good Good Poor Excellent Good Good Coptisine