The role of glutathione S-transferase omega gene polymorphisms in childhood acute lymphoblastic leukemia: a case-control study

Egyptian Journal of Medical Human Genetics

Table 3 GSTO1A140D* and GSTO2N142D* genotypes and allele distribution in the ALL cases, de novo ALL cases, and control groups

	ALL cases [N = 96]	De novo cases [N = 46]	Controls [N = 99]	P value	OR (95% CI)
GSTO1 genotypes
CC	43 (44.8%)	17 (37%)	56 (56.6%)	0.106^a 0.008^b
CA	45 (46.9%)	22 (47.8%)	40 (40.4%)
AA	8 (8.3%)	7 (15.2%)	3 (3.0%)
CA + AA	53 (55.8%)	29 (63%)	43 (43.4%)	0.085^a	1.643(0.932–2.898)^a
CA + AA	53 (55.8%)	29 (63%)	43 (43.4%)	0.028^b	2.222 (1.083–4.558)^b
Alleles
C	131 (68.2%)	56 (60.9%)	152 (76.8%)	Reference
A [minor allele]	61 (31.77%)	36 (39.1%)	46 (23.2%)	0.051^a	1.563(0.997–2.448)^a
A [minor allele]	61 (31.77%)	36 (39.1%)	46 (23.2%)	0.005^b	2.124 (1.24–3.620)^b
GSTO2 genotypes
AA	25 (26.0%)	17 (37%)	36 (36.3%)	0.017^a 0.002^b
AG	60 (62.5%)	21 (45.7%)	61 (61.6%)
GG	11 (11.4%)	8 (17.3%)	2 (2.0%)
AG + GG	71 (73.9%)	29 (63.0%)	63 (63.6%)	0.132^a	1.600(0.866–2.955)^a
AG + GG	71 (73.9%)	29 (63.0%)	63 (63.6%)	0.945^b	0.975 (0.472–2.013)^b
Alleles
A	111 (57.8%)	55 (59.8%)	133 (67.2%)	Reference
G [minor allele]	81 (42.2%)	37 (40.2%)	65 (32.8%)	0.046^a	1.521(1.006–2.298)^a
G [minor allele]	81 (42.2%)	37 (40.2%)	65 (32.8%)	0.220^b	1.37 (0.825–2.296)^b