Table 4 The frequency of GSTO1*A140D and GSTO2*N142D polymorphisms in the high-risk ALL group
Frequency of GSTO1*A140D genotypes in the high-risk ALL group | ||||
GSTO1*A140D | Variant [N = 54] | Wild [N = 42] | P value | |
Age (> 10 years) | 17 (31.4%) | 10 (23.8%) | 0.687 | |
WBCs (> 50 × 109/L) | 28 (51.8%) | 18 (42.8%) | 0.765 | |
T cell phenotype [N (%)] | 21 (38.8%) | 13 (30.9) | 0.650 | |
Frequency of GSTO2*N142D genotypes in the high-risk ALL group | ||||
GSTO2*N142D | Variant [N = 70] | Wild [N = 26] | P value | |
Age (> 10 years) | 22 (31.4%) | 5 (19.2%) | 0.237 | |
WBCs (> 50 × 109/L) | 33 (47.1%) | 13 (50%) | 0.062 | |
T cell phenotype [N (%)] | 23 (32.8%) | 11 (42.3%) | 0.740 | |
Frequency of combined GSTO1*A140D and GSTO2*N142D polymorphisms in the high-risk ALL group | ||||
GSTO1*A140D and GSTO2*N142D polymorphisms | Combined polymorphisms [GSTO1 and GSTO2 variant genotypes] [N = 47] | Single polymorphism [GSTO1 or GSTO2 variant genotypes] [n = 27] | No polymorphism [GSTO1 and GSTO2 wild genotypes] [n = 22] | P value |
Age (> 10 years) | 11 (23.4%) | 5 (18.5%) | 1 (4.5%) | 0.159 |
WBCs (> 50 × 109/L) | 25 (53.1%) | 11 (40.7%) | 10 (45.4%) | 0.567 |
T cell phenotype [N (%)] | 18 (38.2%) | 8 (29.6%) | 8 (36.3%) | 0.574 |