Chronic PIT patients | TNFAIP3 (rs5029939 C>G) SNP | |||
---|---|---|---|---|
Wild genotype (CC) [n = 31] | Mutant heterozygous genotype (CG) [n = 9] | p value | ||
Sex [N (%)] | Males | 15 (48.4) | 2 (22.5) | 0.256 |
Females | 16 (51.6) | 7 (77.8) | ||
Age (mean ± SD) | 7.77 ± 3.7 | 9.4 ± 4.74 | 0.235 | |
Age at initial presentation (mean ± SD) | 4.1 ± 2.63 | 5.91 ± 3.59 | 0.157 | |
Duration of illness (mean ± SD) | 3.7 ± 2.53 | 3.53 ± 2.61 | 0.702 | |
Type of bleeding [N (%)] | Cutaneous | 17 (54.8) | 4 (44.4) | 0.552 |
Mucous | 1 (3.2) | 1 (11.1) | ||
Both | 13 (41.9) | 4 (44.4) | ||
Severity of bleeding | ||||
(IWG bleeding score) [N (%)] | Severe life threatening (4b) | 1 (3.2) | 1 (11.1) | 0.850 |
Severe non-life threatening(4a) | 4 (12.9) | 1 (11.1) | ||
Moderate (3) | 12 (38.7) | 4 (44.4) | ||
Mild (2) | 13 (41.9) | 3 (33.3) | ||
Minor (1) | 1 (3.2) | 0 (0) | ||
Splenectomy [N (%)] | 1 (3.2) | 1 (11.1) | 0.404 | |
HTN [N (%)] | 9 (29) | 4 (44.4) | 0.437 | |
Initial platelet count [× 109/L (mean ± SD)] | 29.42 ± 19 | 43.89 ± 20.36 | 0.064 | |
Platelets at the time of sampling [× 109/l (mean ± SD)] | 111.7 ± 60.59 | 166.11 ± 97.66 | 0.177 | |
Hemoglobin at the time of sampling [g/dl (mean ± SD)] | 10.96 ± 1.42 | 11.07 ± 1.65 | 0.824 | |
TLC at the time of sampling [× 109/l (mean ± SD)] | 10.2 ± 4.42 | 9.33 ± 4.14 | 0.849 | |
Laboratory response [N (%)] | Complete response | 21 (67.74) | 7 (77.7) | 1 |
Response | 5 (16.12) | 1 (11.1) | 0.697 | |
No response | 5 (16.12) | 1 (11.1) | 0.697 | |
Treatment received | ||||
Initial treatment [N (%)] | Watchful waiting | 5 (16.1) | 6 (66.7) | 0.007* |
Corticosteroids | 31 (100) | 9 (100) | ___ | |
IVIg | 4 (12.9) | 0 (0) | --- | |
Platelet transfusion | 1 (3.2) | 1 (11.1) | 0.404 | |
Maintenance treatment [N (%)] | Oral corticosteroids | 26 (83.9) | 9 (100) | 0.570 |
Azathioprine (Imuran) | 19 (61.3) | 5 (55.6) | 1 | |
Cyclosporine (Sand immune) | 5 (16.1) | 3 (33.3) | 0.348 | |
Mycophenolate Mofetil (Cellcept) | 0 (0) | 1 (11.1) | --- | |
Eltrombopag (Revolade) | 2 (6.5) | 0 (0) | --- | |
Oral corticosteroids | 26 (83.9) | 9 (100) | 0.570 |