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Table 1 Clinical features of patients and mutated populations

From: Molecular and environmental characterization of Noonan syndrome in Morocco reveals a significant association with consanguinity and advanced parental age

FeaturesStudied population (31 patientsa)Mutated population (5 patientsa)
Sex ratio1.21.5
 Female14 (45.2%)3 (60%)
 Male17 (54.8%)2 (40%)
Patient average age (range)6.5 years (1 month–17 years)7.66 (4 months–13 years)
Congenital heart disease21 (84%)4 (80%)
 Pulmonary valvular stenosis15 (71.4%)4 (100%)
 Atrial septal defect5 (23%)1 (25%)
 Dilated cardiomyopathy1 (4.7%)0 (0%)
Normal heart4 (16%)1 (20%)
Consanguinity9 (36%)3 (60%)
Reproductive average age (range)
 Maternal reproductive average age31 years (19–42)29 years (22–38)
 Paternal reproductive average age40 years (23–49)38 years (30–49)
  1. aMay vary depending on the available data (i.e., consanguinity data was available in only 25 patients)