Skip to main content

Table 3 Pathogenic effect prediction of PROVEAN and MutationTaster2 programs for PTPN11 missense variants

From: Molecular and environmental characterization of Noonan syndrome in Morocco reveals a significant association with consanguinity and advanced parental age

VariantPROVEAN scorePredictionMutationTaster2 scorePrediction
D61G− 5.64Deleterious94Disease causing
Y63C− 7.06Deleterious194Disease causing
A72S− 2.58Deleterious99Disease causing
N308S− 4.66Deleterious46Disease causing