Table 3 Pathogenic effect prediction of PROVEAN and MutationTaster2 programs for PTPN11 missense variants
Variant | PROVEAN score | Prediction | MutationTaster2 score | Prediction |
|---|---|---|---|---|
D61G | − 5.64 | Deleterious | 94 | Disease causing |
Y63C | − 7.06 | Deleterious | 194 | Disease causing |
A72S | − 2.58 | Deleterious | 99 | Disease causing |
N308S | − 4.66 | Deleterious | 46 | Disease causing |