Long non-coding RNA HOTAIR and HOTTIP as potential biomarkers for hepatitis C virus genotype 4-induced hepatocellular carcinoma

Roshdy, Fawzy; Farag, Mohamed M. S.; El-Ahwany, Eman; Mahmode, Ola; Mousa, Adel A.; El Talkawy, Mohamed; Essawy, Faiza

doi:10.1186/s43042-020-0048-8

Egyptian Journal of Medical Human Genetics

Table 2 Socio-demographic characteristics, laboratory investigations, and ultrasound finding among patients of the studied groups

From: Long non-coding RNA HOTAIR and HOTTIP as potential biomarkers for hepatitis C virus genotype 4-induced hepatocellular carcinoma

		Control n = 25	Group I (CLD without HCC) N = 50		Group II (CLD with HCC) n = 25
		Control n = 25	Subgroup Ia (CLD without cirrhosis) n = 25	Subgroup Ib (CLD with cirrhosis) n = 25	Group II (CLD with HCC) n = 25
Age		47.1 ± 8.5	47.7 ± 9.9	58.9 ± 9.3aa, bb	56.3 ± 7.8aa, bb
Sex Female/male		2(08.0%)/23(92.0%)	15(60.0%)/10(40.0%)aa	12(48.0%)/13(52.0%)aa	6(24.0%)/19(76%)bb, cc
US finding	Cirrhosis	0(0.0%)	0(0.0%)	25(100.0%)	7(28.0%)cc
	Splenomegaly	0(0.0%)	3(12.0%)	19(76.0%)bb	22(88.0%)bb,c
	Ascites	0(0.0%)	0(0.0%)	21(84.0%)	25(100.0%)c
ALT (umol/dl)		27.5 (15.5–31.8)	40.0 (17.0–51.0)a	46.5 (24.3–84.8)a	55.5 (34.5–82.5)aa, bb
AST (umol/dl)		32.0 (24.3–38.0)	38.0 (28.0–46.0)	44.5 (32.0–69.5)aa	80.0 (37.3–111.0)aa, bb, c
AFP (ng/ml)		2.3 (1.5–3.1)	2.2 (1.4–4.5)	8.8 (6.5–16.8)aa, bb	224.0 (44.3–597.5)aa, bb, cc
Albumin (umol/dl)		4.1 ± 0.5	4.1 ± 0.5	3.1 ± 1.1aa, bb	2.6 ± 0.7aa, bb, c
Total bilirubin (umol/dl)		0.9 (0.8–1.1)	0.6 (0.4–0.9)aa	1.4 (0.7–3.6)a, bb	1.9 (1.3–5.0)aa, bb, c
Direct bilirubin (umol/dl)		0.3 (0.2–0.4)	0.2 (0.1–0.3)a	0.6 (0.2–1.9)a, bb	1.1 (0.4–2.5)aa, bb
ALP (IU/L)		74.3 ± 19.0	84.9 ± 30.2	103.2 ± 35.6aa, b	202.4 ± 88.0aa, bb, cc
PT (s)		12.4 (11.4–12.8)	15.4 (13.2–18.8)aa	17.8 (15.0–20.4)aa	16.3 (14.5–19.0)aa
PC (%)		89.6 (78.2–100.0)	64.0 (55.0–80.0)aa	52.5 (44.0–73.8)aa	71.5 (55.0–75.3)aa
INR (s)		1.1 (1.0–1.1)	1.5 (1.0–1.6)aa	1.5 (1.2–1.8)aa	1.4 (1.2–1.5)aa
HB (g/dl)		12.6 ± 1.4	12.4 ± 1.6	10.4 ± 2.2aa, bb	11.2 ± 2.4a, b
WBCs (/mm3)		6.2 ± 2.3	7.0 ± 2.8	7.3 ± 2.6	7.8 ± 3.1
Platelets (/mm3)		241.5 ± 56.5	228.2 ± 67.3	112.9 ± 52.9aa, bb	136.1 ± 82.2aa, bb
APRI score		0.34 ± 0.13	0.61 ± 0.17	1.69 ± 0.31	2.1 ± 1.3

Age, albumin, alkaline phosphates (ALP), hemoglobin (HB), white blood cells (WBCs) and platelets are represented as mean ± SD; the data were analyzed by t test. But sex and ultrasound (U/S) findings are represented as frequency and percent; the data were analyzed by X² test. While alanine aminotransferase (ALT), aspartate aminotransferase (AST), alpha-fetoprotein (AFP), total bilirubin, direct bilirubin, prothrombin time (PT), prothrombin concentration (PC) and international normalized ratio (INR) are represented as median and interquartile range (25%–75%); the data were analyzed by Mann-Whitney U test
p value bearing (b) initial is significantly different comparing with HCV group
p value bearing (c) initial is significantly different comparing with cirrhotic group
p value bearing (#) initial is significantly different comparing with CLD group
1 initial p value <0.05 is significant, 2 initial p value <0.01 is highly significant

Back to article page