Long non-coding RNA HOTAIR and HOTTIP as potential biomarkers for hepatitis C virus genotype 4-induced hepatocellular carcinoma

Egyptian Journal of Medical Human Genetics

Table 4 Biomarkers gene expression in the studied groups

Biomarkers	Control n = 25	Group I CLD without HCC		Group II CLD with HCC n = 25
Biomarkers	Control n = 25	Subgroup Ia (CLD without Cirrhosis) n = 25	Subgroup Ib (CLD with Cirrhosis) n = 25	Group II CLD with HCC n = 25
HOTAIR	0	3.1(2–5.45)^aa	3.6(1.45–9.4) ^aa	12.9(3.95–23.35) ^{aa, bb, c, ##}
HOTTIP	0	2.4(1.15–5.8)^aa	4.6(0.2–19.95) ^aa	14.8(1.55–42.05) ^{aa, b, c, #}

All parameters are represented as median with interquartile range (25%–75%) of the fold change of the studied groups, the data were analyzed by Mann-Whitney U test
p value bearing (a) initial is significantly different comparing with control group
p value bearing (b) initial is significantly different comparing with HCV group
p value bearing (c) initial is significantly different comparing with cirrhotic group
p value bearing (#) initial is significantly different comparing with CLD group
^{1 initial}p value < 0.05 is significant, ^{2 initial}p value < 0.01 is highly significant