Table 6 Diagnostic performances of HOTAIR and HOTTIP to discriminate (cirrhotic and HCC) patients from CLD patients
Biomarkers in the studied groups | Cutoff | Sensitivity | Specificity | PPV | NPV | Accuracy | AUC | 95% CI | p value | |
|---|---|---|---|---|---|---|---|---|---|---|
HOTAIR | Cirrhotic vs non-cirrhotic | 4.7 | 48.0 | 72.0 | 63.2 | 58.1 | 60.0 | 52.0 | 35.6–68.4 | 0.8 |
HCC vs non-cirrhotic | > 9.2 | 64.0 | 96.0 | 94.1 | 72.7 | 80.0 | 78.6 | 65.6–91.7 | < 0.0001** | |
HCC vs cirrhotic | > 7.0 | 64.0 | 76.0 | 72.7 | 67.9 | 70.0 | 69.8 | 55.5–84.1 | 0.007** | |
HCC vs CLD without HCC | > 9.2 | 64.0 | 86.0 | 69.6 | 82.7 | 78.7 | 74.2 | 61.9–86.5 | 0.001** | |
HOTTIP | Cirrhotic vs non-cirrhotic | 13.4 | 32.0 | 100.0 | 100.0 | 59.5 | 66.0 | 53.9 | 37.1–70.8 | 0.64 |
HCC vs non-cirrhotic | > 13.4 | 52.0 | 100.0 | 100.0 | 67.6 | 76.0 | 70.8 | 56.2–85.4 | 0.005** | |
HCC vs cirrhotic | > 34.8 | 36.0 | 92.0 | 81.8 | 59.0 | 64.0 | 65.8 | 51.3–80.4 | 0.03* | |
HCC vs CLD without HCC | > 16.6 | 48.0 | 88.0 | 66.7 | 77.2 | 74.7 | 68.3 | 55.0–81.7 | 0.007** | |