Long non-coding RNA HOTAIR and HOTTIP as potential biomarkers for hepatitis C virus genotype 4-induced hepatocellular carcinoma

Egyptian Journal of Medical Human Genetics

Table 7 Univariate analysis showing the predictive power of different biomarkers for cirrhosis and HCC diagnosis

	Biomarker	OR	95% C.I	p value
Cirrhotic vs non-cirrhotic	HOTAIR	1.111	0.998–1.236	0.05*
Cirrhotic vs non-cirrhotic	HOTTIP	1.07	0.999–1.147	0.05*
HCC vs non-cirrhotic	HOTAIR	1.141	1.026–1.270	0.01*
HCC vs non-cirrhotic	HOTTIP	1.103	1.030–1.182	0.005**
HCC vs cirrhotic	HOTAIR	1.027	0.994–1.062	0.1
HCC vs cirrhotic	HOTTIP	1.029	0.998–1.062	0.05*
HCC vs CLD without HCC	HOTAIR	1.047	1.011–1.084	0.01*
HCC vs CLD without HCC	HOTTIP	1.05	1.017–1.084	0.003**

OR Odd ratio, C.I Confidence interval
p value calculated depend on logistic regression analysis, *p value <0.05 is significant, **p value <0.01 is highly significant