From: Congenital heart diseases: genetics, non-inherited risk factors, and signaling pathways
Candidate gene | CHD phenotype | References |
---|---|---|
NKX2.5 | Tetralogy of Fallot, patent ductus arteriosus, transposition of greater vessels, atrial septal defects with conduction defects, and hypoplastic left heart syndrome | |
MEF2C | Double outlet ventricle, ventricular septal defects, and patent ductus arteriosus | |
GATA4 | Atrial and ventral septal defects | |
TBX5 | Holt-Oram syndrome, ostium secondum defects, tetralogy of Fallot, and ventricular septal defects | |
ANKRD1 | Septal defects | [113] |
NR2F2 | Double outlet ventricle | [112] |
HAND2 | Familial ventral septal defect, pulmonary stenosis, double outlet ventricle, and tetralogy of Fallot | [115] |
CASZ1 | Ventral septal defects | [114] |
MYH6 | Familial atrial septal defects | [89] |
MYH7 | Ebstein anomaly and left ventricular non-compaction | [117] |