The association of apolipoprotein-E (APOE) gene polymorphisms with coronary artery disease: a systematic review and meta-analysis

Egyptian Journal of Medical Human Genetics

Table 2 In each included study the distribution of genotypes and frequencies of APOE allele

Serial no.	Author	Year	Genotypes distribution												Allele frequencies
			Cases						Controls						Cases			Controls
			ε2/2	ε2/3	ε2/4	ε3/3	ε3/4	ε4/4	ε2/2	ε2/3	ε2/4	ε3/3	ε3/4	ε4/4	ε2	ε3	ε4	ε2	ε3	ε4
1	Larifla et al.	2017	2	27	05	100	76	10	5	53	19	241	150	24	8.2	68.9	22.9	8.3	69.6	22.1
2	Abd El-Aziz	2016	---	---	---	---	---	---	---	---	---	-----	----	------	28	192	44	54	209	7
3	Afroze et al.	2015	2	18	4	110	53	13	9	36	12	315	66	12	26	291	83	66	732	102
4	Atis et al.	2016	0	12	1	73	12	2	0	14	0	64	21	0	6.5%	85.5%	8%	8%	81.5%	10.5%
5	Cheema et al.	2015	2	36	06	491	129	08	---	-------	-----	---	-----	----	27	352	112	9	118	19
6	Long et al.	2019	3	34	3	284	67	15	0	21	3	169	32	6	43	669	100	24	391	47
7	Ghaznavi	2018	---	22	3	110	62	3	---	10	2	154	32	2	25	304	71	12	350	38
8	Arafa et al.	2018	---	9	---	59	32	---	---	13	---	73	14	---	9	159	32	13	173	14
9	Heidari	2013	8	---	---	52	6	---	7	---	---	54	0	---	16	110	6	14	108	0
10	Hou et al. 2020	2020	3	66	6	442	125	11	2	91	10	448	92	3	78	1075	153	105	1079	108
11	Souza et al.	2007	0	7	0	76	16	1	2	3	3	68	23	1	7	175	18	10	162	28
12	Djan et al.	2011	---	0	1	16	13	0	---	1	0	19	4	1	1	45	14	1	43	6