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Table 3 Comparison of NKX2.5 mutation rate throughout various tetralogy of Fallot (TOF) populations

From: Screening of NKX2.5 gene in Moroccan Tetralogy of Fallot (TOF) patients: worldwide mutation rate comparisons show a significant association between R25C variant and TOF phenotype

Region

TOF population

Pathogenic mutation rate of NKX2.5 (%)

p value*

Reference

North Africa

Egyptian

1/10 (10)

1

[17]

Egyptian

1/15 (6.7)

1

[18]

Europe

Turkish

1/22 (4.5)

1

[19]

German

4/182 (2)

0.2

[20]

America

American

9/201 (4)

0.6

[14]

American

1/20 (5)

1

[13]

American

6/150 (4)

0.6

[8]

Brazilian

1/58 (1.7)

0.27

[21]

Asia

Chinese

1/15 (6.7)

1

[22]

Chinese (Han)

0/50 (0)

0.1

[23]

Japanese

1/125 (0.8)

0.1

[24]

Present study

Moroccan

2/31 (6.4)

  1. *Compared to our study