Table 1 Overexpressed genes in early breast cancer
Abbreviations | Gene | Function |
|---|---|---|
TP53 | Tumor protein 53 | Tumor suppressor |
PIK3CA | Phosphoinositide-3-kinase-catalytic-alpha polypeptide | Regulates PI3K signalling. PI3K signalling is important for cell proliferation, migration of cells |
ERBB2 (HER2) | Human epidermal growth factor receptor 2 (HER2) | Play an important role in breast cancer progression |
FGFR1 | Fibroblast growth factor receptor 1 | Cell differentiation, growth, proliferation, migration |
MYC | Myelocytomatosis oncogene | Acts as protooncogene |
PTEN | Phosphatase and tensin homolog | Control cell movement, adhesion of cells to surrounding tissues, and helps in angiogenesis. |