Fig. 1From: Mutational analysis of p53 gene in cervical cancer and useful polymorphic variants in exons 3 and 4The HPV E6 oncoprotein induces p53 proteasomal degradation via the ubiquitin degradation pathway. The E6 oncoprotein binds with the ubiquitin-protein ligase E6-associated protein (E6AP). The E6AP-E6 complex associates with p53, E6AP then catalyses multi-ubiquitination of p53 leading to the degradation of p53 [7]Back to article page