Table 6 Overall survival of AML patients in relation to gene polymorphism of CYP2B6 and CYP3A4
N | 9 months Cumulative Survival (%) | Median Survival time (95%CI) (months) | p value | |
|---|---|---|---|---|
Whole group | 50 | 48.5 | 9.0 (7.8-10.2) | |
CYP2B6 | ||||
Wild | 23 | 64.3 | 10.0 (7.8-12.2) | |
Mutant | 27 | 34.9 | 9.0 (8.3-9.7) | 0.827 |
CYP3A4 | ||||
Wild | 31 | 63.5 | 12.0 (8.7-15.3) | 0.030 |
Mutant | 19 | 28.7 | 9.0 (7.8-10.2) | |
Single vs. Combined | ||||
Single Mutation | 18 | 62.2 | 11.0 (8.1-13.9) | 0.030 |
Combined Mutations | 14 | 16.1 | 8.0 (6.3-9.7) | |