Table 9 Relation of HOTAIR expression to standard prognostic factors in AML
From: HOTAIR expression and prognostic impact in acute myeloid leukemia patients
Prognostic factors | HOTAIR (folds of control) | |||||||
|---|---|---|---|---|---|---|---|---|
< = 3.25 | > 3.25 | Test value | p value | Significance | ||||
No. | % | No. | % | |||||
Age (years) | < 60 | 3 | 75.0% | 24 | 77.4% | 0.012 | 0.914 | NS |
≥ 60 | 1 | 25.0% | 7 | 22.6% | ||||
Sex | Female | 3 | 75.0% | 16 | 51.6% | 0.781 | 0.377 | NS |
Male | 1 | 25.0% | 15 | 48.4% | ||||
TLC (×103/uL) | < 100 | 4 | 100.0% | 28 | 90.3% | 0.423 | 0.515 | NS |
≥ 100 | 0 | 0.0% | 3 | 9.7% | ||||
Hb (g/dL) | < 6 | 0 | 0.0% | 2 | 6.5% | 0.274 | 0.601 | NS |
≥ 6 | 4 | 100.0% | 29 | 93.5% | ||||
Platelets (×103/uL) | < 30 | 4 | 100.0% | 17 | 54.8% | 3.011 | 0.083 | NS |
≥ 30 | 0 | 0.0% | 14 | 45.2% | ||||
BM blast % | < 60 | 1 | 25.0% | 12 | 38.7% | 0.285 | 0.593 | NS |
≥ 60 | 3 | 75.0% | 19 | 61.3% | ||||
HSM | No HSM | 4 | 100.0% | 21 | 67.7% | 1.806 | 0.179 | NS |
HSM | 0 | 0.0% | 10 | 32.3% | ||||
Cytogenetics | No cyto | 3 | 75.0% | 27 | 87.1% | 0.423 | 0.515 | NS |
Cyto | 1 | 25.0% | 4 | 12.9% | ||||
Response | Responders | 3 | 75.0% | 24 | 77.4% | 0.012 | 0.914 | NS |
Non-responders | 1 | 25.0% | 7 | 22.6% | ||||
EFS | Free | 3 | 75.0% | 21 | 67.7% | 0.087 | 0.769 | NS |
Relapse | 1 | 25.0% | 10 | 32.3% | ||||