Table 6 Distribution of KCNJ11 (rs 5219) genotype and allelic frequencies in diabetic children compared to controls
From: Association of ABCC8 and KCNJ11 gene variants with type 1 diabetes in south Indians
Inheritance model | Genotype | Diabetes n=60 n (%) | Controls n=60 n (%) | OR (95% CI) | p value |
|---|---|---|---|---|---|
Co dominant | C/C | 15 (25%) | 32 (53.3%) | 1.00 | |
C/T | 17 (28.3%) | 15 (25%) | 2.42 (0.96–6.11) | <0.002* | |
T/T | 28 (46.7%) | 13 (21.7%) | 4.59 (1.87–11.29) | <0.001* | |
Dominant | C/C | 15 (25%) | 32 (53.3%) | 1.00 | |
C/T-T/T | 45 (75%) | 28 (46.7%) | 3.43 (1.58–7.43) | <0.001* | |
Recessive | C/C-C/T | 32 (53.3%) | 47 (78.3%) | 1.00 | |
T/T | 28 (46.7%) | 13 (21.7%) | 3.16 (1.43–7.02) | <0.003* | |
Over dominant | C/C-T/T | 43 (71.7%) | 45 (75%) | 1.00 | |
C/T | 17 (28.3%) | 15 (25%) | 1.19 (0.53–2.67) | 0.68 | |
Allele frequencies | C | 47 (39.1%) | 79 (65.8%) | ||
T | 73 (60.8%) | 41 (34.1%) | 2.978 (1.764–5.076) | <0.006* |