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Egyptian Journal of Medical Human Genetics

Table 2 Comparison of IGFBP-1 DNA methylation of the six combined CPG sites in the studied groups

From: Insulin-like growth factor binding protein 1 DNA methylation in type 2 diabetes

 

Insulin

(N=28)

Oral

(N=22)

Control

(N=50)

^P value

CpG 1

33.0±7.2 a

33.4±7.3 a

26.7±9.5 b

0.001**

CpG 2

29.8±8.1 a

29.9±8.2 a

24.1±10.0 b

0.009**

CpG 3

24.5±10.6 ab

25.5±10.6 a

19.1±11.6 b

0.034*

CpG 4

24.3±10.6 ab

25.4±10.3 a

18.6±11.7 b

0.024*

CpG 5

25.6±10.7 ab

27.0±10.0 a

20.8±11.2 b

0.045*

CpG 6

43.4±24.6 a

46.5±28.6 a

28.0±24.3 b

0.005**

CpG mean

30.1±11.6 a

31.3±12.2 a

22.9±12.6 b

0.008**

  1. ^ANOVA test with post hoc Duncan’s test, homogeneous groups had the same symbol (a, b)
  2. *Significant
  3. **Highly significant
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