Insulin-like growth factor binding protein 1 DNA methylation in type 2 diabetes

Hafez, Sally M.; Abou-youssef, Hazem. El-Sayed; Awad, Mona Abdel-Kader; Kamel, Solaf Ahmed; Youssef, Rasha N.; Elshiekh, Suzan Mahrous; Raslan, Hala; Salah, Nehal

doi:10.1186/s43042-021-00153-0

Egyptian Journal of Medical Human Genetics

Table 4 Linear regression for factors affecting methylation in the T2D patients

From: Insulin-like growth factor binding protein 1 DNA methylation in type 2 diabetes

Marker	Factor	β	SE	P value	95% CI	R²
CpG 1	Constant	24.06	10.32	0.024^a	3.25–44.87	0.373
	Age	0.11	0.16	0.516	−0.22–0.43
	BMI	−0.05	0.12	0.655	−0.30–0.19
	Duration	0.28	0.27	0.307	−0.27–0.83
	Family history	8.49	1.79	<0.001^a	4.88–12.11
	Male	−0.18	1.75	0.919	−3.71–3.36
	Insulin treatment	−2.81	2.56	0.277	−7.97–2.34
CpG 2	Constant	27.11	11.68	0.025^a	3.56–50.67	0.371
	Age	0.05	0.18	0.780	−0.32–0.42
	BMI	−0.17	0.14	0.231	−0.44–0.11
	Duration	0.30	0.31	0.339	−0.32–0.92
	Family history	8.75	2.03	<0.001^a	4.66–12.84
	Male	−1.85	1.98	0.356	−5.86–2.15
	Insulin treatment	−2.81	2.89	0.336	−8.65–3.02
CpG 3	Constant	12.36	15.43	0.427	−18.75–43.47	0.345
	Age	0.18	0.24	0.460	−0.31–0.67
	BMI	−0.12	0.18	0.513	−0.48–0.24
	Duration	0.51	0.41	0.219	−0.31–1.33
	Family history	11.41	2.68	<0.001^a	6.01–16.81
	Male	−1.42	2.62	0.591	−6.70–3.87
	Insulin treatment	−5.23	3.82	0.178	−12.94–2.48
CpG 4	Constant	17.83	14.69	0.231	−11.79–47.44	0.394
	Age	0.05	0.23	0.813	−0.41–0.52
	BMI	−0.12	0.17	0.470	−0.47–0.22
	Duration	0.45	0.39	0.255	−0.34–1.23
	Family history	12.43	2.55	<0.001^a	7.29–17.57
	Male	−0.43	2.50	0.864	−5.46–4.60
	Insulin treatment	−5.02	3.64	0.175	−12.36–2.31
CpG 5	Constant	15.66	14.89	0.299	−14.36–45.69	0.374
	Age	0.15	0.23	0.521	−0.32–0.62
	BMI	−0.16	0.17	0.368	−0.51–0.19
	Duration	0.52	0.39	0.190	−0.27–1.32
	Family history	11.65	2.59	<0.001^a	6.44–16.86
	Male	−0.53	2.53	0.835	−5.63–4.57
	Insulin treatment	−5.68	3.69	0.131	−13.11–1.76
CpG 6	Constant	29.91	37.99	0.435	−46.70–106.52	0.366
	Age	0.17	0.60	0.778	−1.03–1.37
	BMI	−0.39	0.44	0.389	−1.28–0.51
	Duration	1.10	1.00	0.278	−0.92–3.13
	Family history	29.53	6.60	<0.001^a	16.22–42.83
	Male	−2.67	6.45	0.681	−15.69–10.35
	Insulin treatment	−12.78	9.41	0.181	−31.76–6.19
CpG mean	Constant	21.16	16.80	0.215	−12.73–55.04	0.387
	Age	0.12	0.26	0.654	−0.41–0.65
	BMI	−0.17	0.20	0.397	−0.56–0.23
	Duration	0.53	0.44	0.242	−0.37–1.42
	Family history	13.71	2.92	<0.001^a	7.83–19.59
	Male	−1.18	2.85	0.681	−6.94–4.58
	Insulin treatment	−5.72	4.16	0.176	−14.12–2.67

β regression coefficient, SE standard error, CI confidence interval, R² coefficient of determination
^aSignificant

Back to article page