Insulin-like growth factor binding protein 1 DNA methylation in type 2 diabetes

Egyptian Journal of Medical Human Genetics

Table 5 Linear regression for factors affecting methylation in the controls

Marker	Factor	β	SE	P value	95% CI	R²
CpG 1	Constant	18.52	14.85	0.219	−11.37–48.41	0.176
	Age	0.40	0.18	0.030^a	0.04–0.75
	BMI	−0.37	0.33	0.272	−1.04–0.30
	Male	0.63	2.90	0.829	−5.21–6.47
CpG 2	Constant	31.12	15.79	0.055	−0.66–62.90	0.150
	Age	0.29	0.19	0.133	−0.09–0.67
	BMI	−0.67	0.36	0.067	−1.38–0.05
	Male	0.03	3.09	0.993	−6.18–6.24
CpG 3	Constant	7.26	18.25	0.693	−29.49–44.00	0.164
	Age	0.52	0.22	0.021^a	0.08–0.96
	BMI	−0.43	0.41	0.302	−1.26–0.40
	Male	−1.00	3.57	0.780	−8.19–6.18
CpG 4	Constant	18.94	17.82	0.293	−16.93–54.81	0.215
	Age	0.51	0.21	0.021^a	0.08–0.93
	BMI	−0.78	0.40	0.057	−1.59–0.02
	Male	−1.14	3.48	0.745	−8.15–5.87
CpG 5	Constant	8.94	17.17	0.605	−25.63–43.50	0.208
	Age	0.57	0.20	0.008^a	0.15–0.98
	BMI	−0.49	0.39	0.207	−1.27–0.28
	Male	−1.38	3.36	0.683	−8.14–5.38
CpG 6	Constant	29.33	37.22	0.435	−45.59–104.26	0.204
	Age	0.95	0.44	0.038^a	0.06–1.84
	BMI	−1.53	0.84	0.074	−3.22–0.15
	Male	0.91	7.27	0.901	−13.74–15.55
CpG mean	Constant	19.02	19.25	0.328	−19.74–57.78	0.201
	Age	0.54	0.23	0.023^a	0.08–1.00
	BMI	−0.71	0.43	0.107	−1.58–0.16
	Male	−0.33	3.76	0.931	−7.90–7.25

β regression coefficient, SE standard error, CI confidence interval, R² coefficient of determination
^aSignificant