Table 2 The first neighbors of selected nodes (ABL1) of osa-miR1858a, osa-miR1858b, and hsa-miR891a-3p target genes, pathways, and Gene Ontology
miRNA | Target genes | Pathways involved | Biological process involved |
|---|---|---|---|
Hsa-miR891a-3p | NRAS PTPN12 MAPT NTRK2 PPM1B NCKAP1L EPHA7 WASF3 BARD1 RIN1 CLASP1 ABL1 | • RAS signaling • MAPK signaling • Chronic myeloid leukemia • ErbB signaling • MicroRNAs in cancer | • Regulation of apoptotic process • Positive regulation of cell population proliferation • Regulation of MAPK cascade |
Osa-miR1858a and osa-miR1858b | CCND2 NUP98 EPS15 TFRC SEMA6A XIAP PAK2 MEF2D RAC2 SHC4 STAT5B MLLT1 ABL1 CBL BCR SORBS3 EGR1 CD5 PDGFB | • Chronic myeloid leukemia • Pathways in cancer • ErbB signaling • RAS signaling • MicroRNA in cancer • Jak-Stat signaling • MAPK signaling • Hematopoietic cell lineage • Wnt signaling | • Regulation of cell population proliferation • Regulation of apoptotic process • Hemopoiesis • Regulation of MAPK cascade |