Table 1 Baseline characteristics of inflammatory bowel disease (ulcerative colitis and Crohn’s disease) patients and controls
Characteristics | UC (N = 50) | CD (N = 50) | HC (N = 100) | p | |
|---|---|---|---|---|---|
Mean age ± SD; year | 31.5 ± 10.1 | 30.5 ± 9.7 | 31.2 ± 9.8 | 0.864 | |
Gender; N (%) | Male | 28 (56.0) | 28 (56.0) | 57 (57.0) | 0.990 |
Female | 22 (44.0) | 22 (44.0) | 43 (43.0) | ||
Current cigarette-smokers; N (%) | 40 (80.0) | 35 (70.0) | 39 (39.0%) | < 0.001 | |
Disease duration; N (%); year | ≤ 3 | 20 (40.0) | 25 (50.0) | NA | 0.314 |
> 3 | 30 (60.0) | 25 (50.0) | NA | ||
Positive family history; N (%) | 7 (14.0) | 8 (16.0) | NA | 0.779 | |
Disease extension; N (%) | Ulcerative proctitis | 20 (40) | NA | NA | |
Left-sided colitis | 15 (30) | NA | NA | ||
Extensive colitis | 15 (30) | NA | NA | ||
Ileocecal colitis | NA | 43 (86.0) | NA | ||
Ileocecal + colon | NA | 7 (14.0) | NA | ||
Symptoms; N (%) | Abdominal/colon pain | 35 (70.0) | 31 (62.0) | NA | 0.527 |
Diarrhea | 30 (60.0) | 26 (52.0) | NA | 0.546 | |
Fever | 25 (50.0) | 24 (48.0) | NA | 1.000 | |
Extra-intestinal manifestations; N (%) | Aphthous ulcer | 11 (22.0) | 13 (26.0) | NA | 0.308 |
Arthralgia | 32 (62.0) | 40 (80.0) | NA | 0.118 | |
Skin rash | 7 (14.0) | 3 (6.0) | NA | 0.318 | |
Appendectomy | 7 (14.0) | 6 (12.0) | NA | 1.000 | |
Bowel stricture | 2 (4.0) | 5 (10.0) | NA | 0.436 | |
Colostomy | 8 (16.0) | 3 (6.0) | NA | 0.200 | |
Fistula | 10 (20.0) | 6 (12.0) | NA | 0.414 | |
Hemorrhoid | 4 (8.0) | 5 (10.0) | NA | 1.000 | |
Laboratory findings; mean ± SD | Hb (mg/dL) | 11.0 ± 3.0 | 10.5 ± 3.5 | NA | 0.682 |
WBC (× 109/L) | 8.1 ± 3.6 | 7.7 ± 3.1 | NA | 0.783 | |
ESR (mm/h) | 54.3 ± 22.5 | 58.8 ± 42.4 | NA | 0.876 | |
sHLA-G (ng/mL)a | 180.5 ± 27.1 | 168.9 ± 26.3 | 126.8 ± 15.1 | < 0.001 | |