Genetic polymorphism of HLA-G gene (G*01:03, G*01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

Egyptian Journal of Medical Human Genetics

Table 3 Frequency of HLA-G alleles in inflammatory bowel disease patients (ulcerative colitis and Crohn’s disease) and controls

HLA-G allele	Model	HC (N = 100)		UC (N = 50)		p	CD (N = 50)		p	IBD (N = 100)		p
HLA-G allele	Model	N	%	N	%	p	N	%	p	N	%	p
G01:03*	Absent	100	100.0	50	100.0	1.000	50	100.0	1.000	100	100.0	1.000
G01:03*	Present	0	0.0	0	0.0		0	0.0		0	0.0
G01:04*	Absent	61	61.0	19	38.0	0.009	13	26.0	< 0.001	32	32.0	< 0.001
G01:04*	Present	39	39.0	31	62.0		37	74.0		68	68.0
G01:05N*	Absent	95	95.0	41	82.0	0.016	40	80.0	0.007	81	81.0	0.004
G01:05N*	Present	5	5.0	9	18.0		10	20.0		19	19.0

HC healthy controls, UC ulcerative colitis, CD Crohn’s disease, IBD inflammatory bowel disease, p two-tailed Fisher exact probability compared to controls (significant p value is indicated in bold)