Genetic polymorphism of HLA-G gene (G*01:03, G*01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

Egyptian Journal of Medical Human Genetics

Table 4 Logistic regression analysis of HLA-G01:04* and HLA-G01:05N* alleles in inflammatory bowel disease patients (ulcerative colitis and Crohn’s disease)

Comparison	HLA-G allele	Model	OR (95% CI)	p	pc
UC vs. HC	G01:04*	Absent	Reference
		Present	2.55 (1.27–5.13)	0.009	0.018
	G01:05N*	Absent	Reference
		Present	4.17 (1.32–13.21)	0.016	0.032
CD vs. HC	G01:04*	Absent	Reference
		Present	4.45 (2.11–9.41)	< 0.001	< 0.001
	G01:05N*	Absent	Reference
		Present	4.75 (1.53–14.78)	0.007	0.014
IBD vs. HC	G01:04*	Absent	Reference
		Present	3.32 (1.86–5.95)	< 0.001	< 0.001
	G01:05N*	Absent	Reference
		Present	4.46 (1.59–12.47)	0.004	0.008
UC vs. CD	G01:04*	Absent	Reference
		Present	0.57 (0.25–1.33)	0.284	0.496
	G01:05N*	Absent	Reference
		Present	0.88 (0.33–2.36)	1.000	1.000

UC ulcerative colitis, CD Crohn’s disease, IBD inflammatory bowel disease, HC healthy controls, vs. versus, OR odds ratio, CI confidence interval, p two-tailed Fisher’s exact probability, pc Bonferroni-corrected probability (significant p value is indicated in bold)