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Table 2 Laboratory results of the studied groups

From: Role of engulfment and cell motility 1 (ELMO1) gene polymorphism in development of diabetic kidney disease

Variables

Group1

(n=100)

Group2

(n=102)

Group 3

(n=102)

P value of Kruskal-Wallis test

Post hoc test

FBS (mg/dl)

P1 0.062

 Mean ±SD

169.72 ± 34.19

158.62 ± 33.76

85.45 ± 7.38

<0.001

P2 <0.001

 Median (IQR)

177(138–188)

156.5 (128–180)

87 (80–90)

 

P3 <0.001

2-hPPG (mg/dl)

P1 0.249

 Mean ±SD

273.38 ± 52.26

262.16 ± 40.43

125.49 ± 12.32

<0.001

P2 <0.001

 Median (IQR)

266 (228–311)

258 (245–288)

123(120–129)

 

P3 <0.001

HbA1c %

P1 <0.001

 Mean ±SD

8.30 ± 0.83

7.44 ± 0.85

4.83 ± 0.25

<0.001

P2 <0.001

 Median (IQR)

8.2 (7.6–8.8)

7.3 (6.9–7.9)

4.8 (4.6–5.0)

 

P3 <0.001

Creatinine (mg/dl)

P1 <0.001

 Mean ±SD

1.41 ± 0.23

1.00 ± 0.11

0.86 ± 0.11

<0.001

P2 <0.001

 Median (IQR)

1.4(1.3–1.5)

1.0(0.9–1.1)

0.90 (0.80–1.0)

 

P3 <0.001

eGFR (mL/min/1.73 m2)

P1 <0.001

 Mean ±SD

54.81 ± 12.80

84.37 ± 10.80

99.52 ± 10.41

<0.001†

P2 <0.001

 Median (IQR)

54.65(46.55–62.84)

81.78 (76.68–89.86)

97.76 (93.16–106.46)

 

P3 <0.001

Total cholesterol (mg/dl)

    

P1 0.552

 Mean ±SD

 Median (IQR)

247.40 ± 23.78

250(225–269)

243.72 ± 19.80

239(231–262)

162.13 ± 14.89

161(154–176)

<0.001

P2 <0.001

P3 <0.001

Triglyceride (mg/dl)

P1 0.994

 Mean ±SD

181.08 ± 20.86

181.86 ± 28.22

127.84 ± 11.20

<0.001

P2 <0.001

Median (IQR)

183 (168–196)

185 (174–198)

128(122–135)

 

P3 <0.001

HDL-C (mg/dl)

P1 0.145

 Mean ±SD

35.22 ± 4.77

36.37 ± 3.42

49.41 ± 5.45

 

P2 <0.001

 Median (IQR)

35(32–39)

38 (34–39)

49(45–54)

<0.001

P3 <0.001

LDL-C (mg/dl)

    

P1 0.044

 Mean ±SD

177.94 ± 22.12

170.25 ± 18.47

86.49 ± 10.60

<0.001

P2 <0.001

 Median (IQR)

182(155–195.8)

168 (155–168)

87 (79–98)

 

P3 <0.001

AIP

P1 0.008

 Mean ±SD

0.37 ± 0.09

0.34 ± 0.05

0.05 ± 0.06

<0.001

P2 <0.001

 Median (IQR)

0.36 (0.32–0.42)

0.34 (0.31–0.38)

0.05 (0.0–0.10)

 

P3 <0.001

ACR (mg/g creatinine)

P1 <0.001

 Mean ±SD

132.14 ± 82.21

18.09 ± 5.72

15.21 ± 5.65

<0.001

P2 <0.001

 Median (IQR)

98 (85–150)

18 (14–22)

15 (11–19)

 

P3 0.001

  1. Group 1 DKD patients, Group 2 diabetic patients without DKD, Group 3 healthy controls, FBS fasting blood sugar, 2-hPPG 2-hour post prandial blood sugar, HbA1c hemoglobin A1C, eGFR estimated glomerular filtration rate, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, AIP atherogenic index of plasma, ACR albumin/creatinine ratio, P1 group 1 vs group 2, P2 group 1 vs group 3, P3 group 2 vs group 3, for ANOVA test, IQ interquartile range. Statistically significant at p ≤ 0.05