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Table 2 Genotype and allelic frequencies of the FOXO3 gene variants compared between octogenarians and gastrointestinal tract cancer patients

From: rs2253310 and rs4946936 common variants of FOXO3 gene in octogenarians and cancer: a pilot study in north India

Reference sequence

Genomic position

Genotype

Octogenarians N=16

GIT cancer patients N=09

χ2

OR

(95% CI)

P value

rs2253310

g.7556C>G (108567390)

CC

10 (0.625)

6 (0.666)

12

0.93

(0.516–1.705)

0.213

CG

6 (0.375)

3 (0.333)

1.12

(0.367–3.447)

GG

0

0

 

Allele frequency

     

C

26 (0.812)

15 (0.833)

6.5

0.975

(.748–1.27)

0.159

G

6 ( 0.187)

3 (0.166)

1.12

(.319–3.96)

rs4946936

g.122284T>C (9108682118)

TT

9 (0.562)

4 (0.444)

6.5

1.26

(0.542–2.957)

0.159

TC

7 (0.437)

5 (0.556)

0.788

(0.352–1.764)

CC

0

0

 

Allele frequency

     

T

25 (0.781)

13 (0.722)

6

0.788

(.292–2.12)

0.199

C

7 (0.218)

5 (0.278)

1.08

(.77–1.52)

  1. Results are given as an N (%). No statistically significant difference χ2 (chi-square test) was found in the frequency of either variants between octogenarians and GIT cancer patients; OR (odds ratio) with 95% confidence interval