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Fig. 3 | Egyptian Journal of Medical Human Genetics

Fig. 3

From: In vitro characterization of human bone marrow mesenchymal stem cell-derived motor neurons induced by epigenetic modifiers

Fig. 3

Quantitative gene expression. The expression of ISLET-1, ChAT, and MNX-1 was evaluated in human BM-MSCs at 7 and 14 days after induction in comparison with the control group (non-treated BM-MSCs) (n=3; mean ± SE; p≤0.05). The expression of motor neuron-related genes (ISLET-1 and CHAT) and histone-modifying enzyme genes (P300 and EZH-2) was significantly upregulated at the second week of induction when RA and Shh were removed. Significant upregulation in the expression of EZH-2 was also detected at week 1 when the result was compared to the control. No upregulation was detected in the expression of MNX-1 when the results were compared with the control

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