Fig. 5From: Recent advances in pharmacological diversification of Src family kinase inhibitorsOutline of Src family kinase in renal disease. Damage in the kidney induced Src kinase activation that causes transactivation of EGFR. Transactivated EGFR stimulates the overproduction of TGF-1 and similarly Smad3 signaling, a pathway for activation of renal fibroblasts and accumulation in extracellular matrix proteins. Smad3 also plays a role in mediating Hck-induced renal fibrosis and STAT3 required for Src- and Fyn-stimulated profibrotic responses in the kidneyBack to article page