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Fig. 5 | Egyptian Journal of Medical Human Genetics

Fig. 5

From: Recent advances in pharmacological diversification of Src family kinase inhibitors

Fig. 5

Outline of Src family kinase in renal disease. Damage in the kidney induced Src kinase activation that causes transactivation of EGFR. Transactivated EGFR stimulates the overproduction of TGF-1 and similarly Smad3 signaling, a pathway for activation of renal fibroblasts and accumulation in extracellular matrix proteins. Smad3 also plays a role in mediating Hck-induced renal fibrosis and STAT3 required for Src- and Fyn-stimulated profibrotic responses in the kidney

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