Recent advances in pharmacological diversification of Src family kinase inhibitors

Egyptian Journal of Medical Human Genetics

Table 5 Src kinase inhibitors in response to acute inflammation

Injury	Animal	Src kinase inhibitors	Key findings	Ref
ALI	Rat	PP2 (0.2 mg/kg iv)	Reduced alveolar macrophage priming and ALI	[63]
ALI	Mouse	PP2 (1 mg/kg, ip), SU-6656 (8 mg/kg, ip)	Reduced LPS- induced ALI and lethal-dose LPS-induces mortality	[64]
Brain injury	Rat	PP1 (2 mg/kg, ip)	Reduced brain edema and mortality	[65, 66]
Ischemic brain injury	Rat	PP2 (1.5 mg/kg, iv)	Reduced brain infarct size	[65, 66]
MI	Rat	PP1 (5 mg/kg, ip)	Reduced edema and tissue injury	[67]
MI	Mouse	PP1 (1.5 mg/kg, ip)	Reduced edema and tissue injury	[67]
Stroke	Mouse	PP1 (1.5 mg/kg, ip)	Suppressed vascular permeability	[68]

ALI acute lung injury, PP 4-amino-5-(4-methylphenyl)-7-(t-butyl) pyrazolo[3,4-d]-pyrimidine