Recent advances in pharmacological diversification of Src family kinase inhibitors

Egyptian Journal of Medical Human Genetics

Table 6 Effects of Src kinase inhibitors in chronic kidney disease

Src inhibitor	Effects of Src inhibitor	Ref
PP2	Ameliorate glomerulosclerosis	[88]
PP2	Block Col4 expression	[89]
PP2 SU-6656	Hinder the activation of TACE, EGFR, MAPK, and collagen IV accumulation	[90]
PP2	Prevent albuminuria, glomerular matrix protein accumulation, GBM thickening, and podocyte depletion	[90]
PP2	Decrease levels of blood urea nitrogen and serum creatinine, triglyceride, and urine albumin	[91]
SKI-606	Reduce renal epithelial cell matrix adhesion, proliferation, and cyst formation	[92]
SKI-606	Ameliorate renal cyst formation and biliary ductal abnormalities	[93]

Col4, collagen 4; TACE, tumor necrosis factor-converting enzyme; EGFR, epidermal growth factor receptor; MAPK, mitogen-activated protein kinase; GBM, glomerular base membrane